ENIGMA MEG Working Group

The ENIGMA Consortium
The ENIGMA MEG Working Group

Enigma Project - MEG working group

The goal of the ENIGMA MEG Working Group is to explore the spatiotemporal patterns of brain oscillatory activity, and determine how these patterns relate to age, gender, and common genetic variants. Data from numerous modalities have demonstrated a hierarchical organization of the brain from sensory systems to higher cortical areas. There is some evidence that this hierarchical organization may also be reflected in the spatial distribution of intrinsic timescales of activity. This ENIGMA working group intends to explore these patterns across the lifespan. To achieve the highest possible number of subjects, this needs to be done by meta-analysis.

Allison Nugent, PhD, ENIGMA MEG Chair
Jeff Stout, PhD, Lead Scientist
Anna Namyst, BA, Project Coordinator

MEG Working Group: Participating Institutions

Global Participation in the ENIGMA MEG Working Group

• Advent Health for Children
• Arkansas Childrens Hospital
• Aston University, UK
• Cambridge University
• Children's Hospital of Philadephia
• DNISC (Università degli Studi G.D'Annunzio Chieti Pescara)
• IRCCS San Camillo Hospital Venice
• Johannes Gutenberg University, Mainz, Germany (Biomedical statistics and multimodal signal processing Unit)
• Macquarie University
• Massachusetts General Hospital
• McGill University, Montreal Neurological Institute
• National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, Karnataka, India
• Nemours DuPont Hospital for Children
• NeuroSpin
• New York University and NYU Abu Dhabi
• NIH/NICHD
• NIH/NIMH
• Precision Medicine Centre, Hokuto Hospital
• Precision Medicine Centre, Kumagaya General Hospital
• Salisbury VA Medical Center, Wake Forest University, Wake Forest School of Medecine
• The Mind Research Network
• Thomas Jefferson University
• Universiti Sains Malaysia
• Universiti Teknologi PETRONAS
• University of Alabama, Birmingham
• University of Göttingen
• University of Jyväskylä, Finland
• University of Pittsburgh
• University of Pittsburgh
• University of Texas Southwestern
• University of Tübingen

If you are interested in participating in this project, please email the project coordinator, Anna Namyst, for more information.

Data Analysis

Data analysis will be available in two flavors: 1. Upload coregistered anonymized data to NIH 2. Perform analysis at acquisition site using EnigmaMeg scripts

• ENIGMA MEG Pipeline on GitHub
• Processing Pipeline FAQ

Upload Data to be analyzed on NIH Biowulf cluster

Instructions for data preparation and upload:

 ENIGMA MEG Data Upload

Potential MEG Subanalyses

 Healthy Volunteers
 Epilepsy
 Alzheimer's and dementia
 Motor Analysis
 Language Processing
 Anxiety Disorders
 Schizophrenia and related disorders
 Developmental disorders
 Traumatic Brain Injury
 Stroke